Search results for "Preliminary Data"

showing 5 items of 5 documents

Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study

2017

Abstract Background Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated plasma levels of LDL-cholesterol that confers an increased risk of premature atherosclerotic cardiovascular disease. Early identification and treatment of FH patients can improve prognosis and reduce the burden of cardiovascular mortality. Aim of this study was to perform the mutational analysis of FH patients identified through a collaboration of 20 Lipid Clinics in Italy (LIPIGEN Study). Methods We recruited 1592 individuals with a clinical diagnosis of definite or probable FH according to the Dutch Lipid Clinic Network criteria. We performed a parallel sequencing of the major…

0301 basic medicineApolipoprotein ECandidate geneSettore MED/09 - Medicina InternaDatabases FactualApolipoprotein BDNA Mutational AnalysisFamilial hypercholesterolemia030204 cardiovascular system & hematologyCompound heterozygosityPCSK90302 clinical medicineRisk FactorsReceptorsGeneticsHomozygoteAutosomal dominant traitPathogenic variantsGeneral MedicinePrognosisAPOB; Familial hypercholesterolemia; LDLR; PCSK9; Pathogenic variantsCholesterolPhenotypeItalyAutosomal Recessive HypercholesterolemiaApolipoprotein B-100lipids (amino acids peptides and proteins)Proprotein Convertase 9APOBCardiology and Cardiovascular MedicinePreliminary DataGenetic MarkersFamilial hypercholesterolemiaLDLRPCSK9APOBPathogenic variantsHeterozygoteFamilial hypercholesterolemiaBiologyPathogenic variantLDLHyperlipoproteinemia Type II03 medical and health sciencesDatabasesmedicineInternal MedicineHumansAPOB; Familial hypercholesterolemia; LDLR; Pathogenic variants; PCSK9; Internal Medicine; Cardiology and Cardiovascular MedicineGenetic Predisposition to DiseaseFactualPCSK9Settore MED/13 - ENDOCRINOLOGIAAPOB; Familial hypercholesterolemia; LDLR; Pathogenic variants; PCSK9; Cardiology and Cardiovascular Medicine; Internal Medicinemedicine.diseaseAtherosclerosis030104 developmental biologyLDLRReceptors LDLMutationbiology.proteinAPOB; Familial hypercholesterolemia; LDLR; Pathogenic variants; PCSK9; Apolipoprotein B-100; Atherosclerosis; Cholesterol; DNA Mutational Analysis; Databases Factual; Genetic Markers; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Hyperlipoproteinemia Type II; Italy; Phenotype; Preliminary Data; Prognosis; Proprotein Convertase 9; Receptors LDL; Risk Factors; Mutation; Internal Medicine; Cardiology and Cardiovascular Medicine
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Possible role of polycyclic aromatic hydrocarbons in the onset of melanoma: preliminary data.

2019

Air PollutantsSkin Neoplasmsbusiness.industryMelanomaMEDLINEDermatologypolycyclic aromatic hydrocarbons melanomamedicine.diseaseBioinformaticsInfectious DiseasesText miningRisk FactorsSettore MED/35 - Malattie Cutanee E VenereeMedicineHumansPolycyclic Aromatic HydrocarbonsbusinessMelanomaPreliminary Data
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SARS‐CoV‐2‐reactive interferon‐γ‐producing CD8+ T cells in patients hospitalized with coronavirus disease 2019

2020

Abstract There is limited information on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) T‐cell immune responses in patients with coronavirus disease 2019 (COVID‐19). Both CD4+ and CD8+ T cells may be instrumental in resolution of and protection from SARS‐CoV‐2 infection. Here, we tested 25 hospitalized patients either with microbiologically documented COVID‐19 (n = 19) or highly suspected of having the disease (n = 6) for presence of SARS‐CoV‐2‐reactive CD69+ expressing interferon‐γ (IFN‐γ) producing CD8+ T cells using flow‐cytometry for intracellular cytokine staining assay. Two sets of overlapping peptides encompassing the SARS‐CoV‐2 Spike glycoprotein N‐terminal 1 to 643 am…

MaleMyeloma proteinCD8-Positive T-LymphocytesAntibodies ViralLymphocyte ActivationCD8+ T cellsSARS‐CoV‐2Blood cell03 medical and health sciencesInterferon-gamma0302 clinical medicineImmune systemAntigenCOVID‐19Intensive careVirologyCytotoxic T cellMedicineHumans030212 general & internal medicineResearch ArticlesAgedAged 80 and overbiologybusiness.industryfungiCOVID-19T‐cell immunityMiddle AgedVirologyHospitalizationmedicine.anatomical_structureInfectious DiseasesImmunoglobulin GSpike Glycoprotein Coronavirusbiology.protein030211 gastroenterology & hepatologyFemaleAntibodybusinessCD8Preliminary DataResearch ArticleJournal of Medical Virology
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Single-centre experience and preliminary Results of intravascular ultrasound in endovascular aneurysm repair

2019

Background Intravascular ultrasound (IVUS) has been introduced as diagnostic adjunct to provide new insights into the diagnosis and therapy of vascular disease. Herein, we compared the outcomes of conventional endovascular aneurysm repair (EVAR) and EVAR with IVUS in patients presenting with infrarenal abdominal aortic aneurysm using a propensity-matched cohort. Methods From May 2013 to August 2017, 221 patients were retrospectively analyzed. Of that, 122 patients were eligible for inclusion and underwent propensity score matching. Perioperative mortality and morbidity, renal function impairment, endoleak incidence, mean contrast medium usage, operative time, radiation exposure (including f…

MaleTime Factorsmedicine.medical_treatmentContrast MediaPredictive Value of TestEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareAortic aneurysmRetrospective StudieRisk FactorsIntravascular ultrasoundFluoroscopyAged 80 and overmedicine.diagnostic_testEndovascular ProceduresGeneral MedicineMiddle AgedRadiation ExposureAbdominal aortic aneurysm2746 SurgeryTreatment OutcomeItalyFemaleRadiologyCardiology and Cardiovascular Medicinerenal function impairmentHumanPreliminary Datamedicine.medical_specialtyTime Factor610 Medicine & healthRadiation DosageAortography2705 Cardiology and Cardiovascular Medicineintravascular ultrasoundBlood Vessel Prosthesis ImplantationEndovascular aneurysm repaircontrast mediumPredictive Value of Testsmedicinefluoroscopy timeHumansUltrasonography InterventionalAgedRetrospective StudiesEndovascular Procedurebusiness.industryRisk FactorAngiography Digital SubtractionPerioperativeDigital subtraction angiographymedicine.disease10020 Clinic for Cardiac SurgeryAngiographySurgerybusinessAortic Aneurysm Abdominal
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Real world evidence on treatment of chronic spontaneous urticaria with omalizumab: Preliminary data.

2020

medicine.medical_specialtyUrticariabusiness.industryDermatologyGeneral MedicineOmalizumabOmalizumabReal world evidenceTreatment Outcomeclinical evaluation and treatmentAnti-Allergic AgentsChronic DiseasemedicineHumansChronic UrticariaIntensive care medicinebusinessdermatologic therapymedicine.drugPreliminary DataDermatologic therapyREFERENCES
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